Q Natal Slide 1

QNatal Advanced

$415 CAD

QNatal® Advanced is a non-invasive cell-free DNA (cfDNA) prenatal screen that screens for the most common fetal aneuploidies, including Down syndrome. In addition, if elected, QNatal Advanced can screen for certain microdeletions and/or fetal sex


  • A simple maternal blood draw performed as early as 10 weeks into the pregnancy
  • Confidential results in 7 to 10 days

Collection method

  • Blood sample – visit an Alpha Labs Patient Service Centre

About this test

QNatal Advanced screens for the most common autosomal fetal abnormalities: trisomy 21 (Down syndrome), trisomy 18 (Edwards syndrome), and trisomy 13 (Patau syndrome). It can also screen for abnormalities of the sex chromosomes. These include Turner syndrome (monosomy X) and Klinefelter syndrome (XXY) as well as XXX and XYY syndromes. In addition, if elected, QNatal Advanced can screen for microdeletions that are too small to be detected by standard cytogenetic analysis. These include microdeletions of chromosomes 1p (1p36 syndrome), 4p (Wolf-Hirschhorn syndrome), 5p (Cri-du-chat syndrome), 8q (Langer-Giedion syndrome), 11q (Jacobsen syndrome), 15q (Prader-Willi/Angelman syndromes), and 22q (DiGeorge syndrome).

This test can be used for all pregnant women.

Q Natal Stat Image

The QNatal Advanced test is performed on cell-free DNA (cfDNA) isolated from maternal blood. This cfDNA contains both maternal DNA and fetal DNA derived from apoptotic placental cells (trophoblasts). Once isolated, the cfDNA is sequenced using massively parallel shotgun sequencing (MPSS); this is followed by quantitative bioinformatics analysis. In this way, the fetal copy number of chromosomes 21, 18, 13, X, Y, as well as select microdeletion regions, are calculated.